conventional Chinese herbs, Dendrobium,
have been utilized as a part of the planning of natural medications into
numerous synthetic medications. Since the dried stems could be utilized broadly
for the treatment of salivary, ophthalmic disorders, fever and chronic
gastritis, Dendrobiumdenneanum has
been listed in the Pharmacopeia of the People’s Republic of China. To
illustrate the pharmacological impacts of Dendrobium
species, much research has been completed on the low sub-atomic components, for
example, bibenzyls,coumarins, alkaloids,phenanthrenes.
phenanthrene and fluorenone are the principle components in Dendrobiumspecies with more than 60
structures discovered yet. Pharmacological examinations have shown that some of
them, for example, erianin, moscatilinexhibited antitumor, angiogenic, antiplatelet
action, antiinflammation and immunoregulatory activities.
Moscatilinwhich was obtained from
aqueous extractsDendrobiumnobile stem,
this bibenzyl compound has antimutagenic action on some mutagens, some other
components isolated from the same
extracts are furylfuramide, 4-nitroquinoline-1-oxide (4NQO), N-methyl-N’- nitro-Nnitrosoguanidine,
3-amino-1,4-dimethyl-5H-pyrido4,3bindole (Trp-P-1), benzoapyrene
(BaP),and aflatoxin B(1) was also reported to have antimutagenic property.
Aqueous extracts of leaves of Dendrobiumnobile created a changes in
gastric acidity output, serum gastrin and plasma somatostatinconcentration.
Experiments were led to consider the impact of dendrobineisolated from leaves
of Dendrobiumnobile which diminished
?-alanine and taurine-prompted depolarizations of essential afferent terminals,
while having little impact upon GABA-and glycine-instigated depolarizations.
Dendrobine (10-5 M) reversibly blocked presynaptic inhibition caused by
antidromic conditioning stimulation of the ventral root.
generally in south China and has been recorded in Chinese Pharmacopeia the
stems of this plant is locally known as “ShiHu” or ‘HuangCao’ is
widely used as Chinese folk medicine. Subsequently it has been accounted that denbinobin
whichwas isolated from stems of Dendrobiummoniliforme
demonstrated potent anti-inflammatory actionin
vitro. In ethyl acetate extracts of Dendrobiummoniliformea
was identifiedwhich suppressed protein tyrosine phosphatase(DS-PTPase) enzyme
activitywhen tested in rats.2,6-dimethoxy-1,4,5,8-phenanthradiquinone isolated
from chloroform extracts of Dendrobiumsuciphylum was found to havepotent
anti-inflammatoryactivity in vitro.
2,6-Dimethoxy-1, 4-benzoquinone, Heptacosane
(C27H56) and octacosanol (C28H58O)
which has been found to havemarked anti-inflammatory
activity in carrageenan inducedoedema in rats and micesareisolated from roots
and stems of Dendrobiumcadidanum. Scopoletin and scoparone which exhibit invitro antiplatelet
aggregation activity has been isolated from Dendrobiumdensiflorum.
Several compounds with anti-inflammatory
activities were isolated from Dendrobiummonoliform.
7-hydroxy-5,6-dimethoxy-1,4-phenanthrenequinone isolated from Dendrobiummoniliformehas
shown inhibitory effect on VHR dual specificity protein tyrosine phosphatase
activity, whereas Dendroside A, C and vanilloside from the same source have
shown stimulatory effect on proliferation of B cells and inhibitory effect on
proliferation of T cells.